ngwaahịa
L-Glutathione dị elu belatara CAS 70-18-8 maka nlekọta anụ ahụ Glutathione
Nkọwa ngwaahịa
MF: C10H17N3O6S
MW: 307.32
Ọnọdụ: 70-18-8
1.Glutathione bụ ngwongwo tripeptide jikọtara ya na glutamic acid, cysteine na glycine site na njikọ peptide.Ọ bụ mercaptan dị ala dị ala kachasị mkpa na mkpụrụ ndụ mammalian n'okpuru nrụgide antioxidant.
2.Glutathione (GSH) bụ ngwongwo tripeptide kpụrụ site na condensation nke glutamic acid, cysteine na glycine site na njikọ peptide.Aha kemịkal ya bụ γ- Usoro nhazi nke l-glutamyl-l-cysteyl-glycine ka egosiri na ọgụgụ 1chemicalbook.Dị ka usoro nhazi dị na ọnụ ọgụgụ a, GSH dị iche na peptides na protein ndị ọzọ.Enwere njikọ peptide pụrụ iche n'ime molecule ya, nke emere nke glutamic acid γ-Carboxyl (- COOH) na cysteine α- Peptide njikọ nke kpụrụ site na condensation nke amino – (- NH2).
3.The molekụla arọ nke glutathione bụ 307.33, na-agbaze ebe bụ 189 ~ 193 ℃ (decomposition), kristal bụ enweghị colorless, transperent, slender kọlụm, na isoelectric ebe bụ 5.93.Ọ bụ soluble na mmiri, itughari mmanya, mmiri mmiri amonia na methyl formamide, ma insoluble na mmanya, ether na acetone.Naanị GSH nwere ọrụ physiological na organism, na GSSG nwere ike rụọ ọrụ ya dị mkpa physiological mgbe mbelata.GSH adịghị mfe ịchekwa n'okpuru ọrụ mmiri dị elu, a pụkwara ịchekwa ya nke ọma ruo ogologo oge naanị mgbe a na-achịkwa ọrụ mmiri n'okpuru 0.3.Nnyocha egosiwo na na vitamin ccchemicalbook aqueous solution nwere GSH (ph3.3), n'ihi na mbelata siri ike nke vitamin C, GSH na ngwọta agaghị oxidized na GSSG, ma ya decomposition ọsọ accelerated;GSSG na vitamin C ngwọta mmiri agaghị agbanwe ka ọ bụrụ GSH, na nkwụsi ike nchekwa ya dị ezigbo mma.Ọzọkwa, GSSG nke a na-etinye n'ọnụ nwere ike ibelata GSH na akụkụ elu nke eriri afọ, na elu nke obere sel epithelial intestinal γ-GTP (nke na-emebi GSH n'ime glutamic acid na Cys Gly) na dipeptidase nwekwara ike igwu egwu physiological dị mkpa. ọrụ.
4.Glutathione dị n'ọtụtụ ebe na anụmanụ na osisi, na ọdịnaya ya na yist na-eme achịcha, germ wheat na imeju anụmanụ dị elu, ruo 100 ~ 1000mg/100g;Ọ nwekwara ọgaranya na ọbara mmadụ na anụmanụ, dị ka 26chemicalbook ~ 34mg/100g n'ime ọbara mmadụ, 58 ~ 73mg/100g n'ime ọbara ọkụkọ, 10 ~ 15mg/100g na ọbara ezi na 14 ~ 22mg/100g n'ime ọbara nkịta.A na-ahụkwa GSH n'ọtụtụ akwụkwọ nri, poteto na ọka.
Ngwa
1.Reduced glutathione bụ obere peptide molecule, nke dị n'ọtụtụ n'ime ihe ndị dị ndụ, karịsịa na mkpụrụ ndụ imeju.Ọ nwere ike ichekwa akpụkpọ ahụ cell imeju, kwalite ọrụ enzyme imeju, ma jikọta ya na ọtụtụ kemịkalụ na-egbu egbu na akwụkwọ kemịkal iji mebie.Ọ nwere mmetụta dị mma na mmerụ ahụ imeju, imeju imeju na ọrịa ndị ọzọ kpatara nsị ọgwụ ọjọọ, ịṅụbiga mmanya ókè na ihe ndị ọzọ.
2.Ọ nwere ọrụ nke antioxidation, scavenging free radicals, detoxification, ịkwalite mgbochi, na-egbu oge ịka nká, mgbochi ọrịa cancer, mgbochi radieshon na ihe ndị ọzọ.
3.Biochemical reagents na antidotes na-tumadi ji maka nsị nke arọ ọla, acrylonitrile, fluoride, carbon monoxide na organic solvents.
4.Endogenous antioxidants na-arụ ọrụ dị mkpa na Mbelata reactive oxygen ụdị kpụrụ n'oge cell metabolism na mberede respiration.Glutathione-S-transferase na-akwalite nhazi nke glutathione sulfide na xenobiotics, leukotrienes na ụmụ irighiri ihe ndị ọzọ nwere ebe electrophilic.Glutathione na-emepụtakwa njikọ disulfide na ihe fọdụrụ nke cysteine na protein.Site na usoro ndị a, ọ nwere ike inwe mmetụta dị ịtụnanya nke ibelata nrụpụta nke ndị na-egbochi ọrịa cancer.
