ngwaahịa
Tetracaine hydrochloride
Nkọwa ngwaahịa
MF: C15H25ClN2O2
MW: 300.82
Ọnọdụ: 136-47-0
1. Tetracaine hydrochloride bụ ọgwụ anestetiiki mpaghara na-arụ ọrụ nke ukwuu nke nwere ike igbochi ọrụ irighiri akwara.A na-eji ya eme ihe na nhụsianya infiltration, akwara mgbochi anesthesia, epidural anesthesia, wdg. ma e jiri ya tụnyere procaine, mmetụta nkwụsịtụ mpaghara ya dị ịrịba ama, a na-ejikwa ya na ụlọ ọgwụ.Site n'ịmụ ụzọ njikọ dị ugbu a, a na-achọpụta na njikọ nke etiti p-butylamino benzoic acid bụ isi nzọụkwụ na njikọ nke tetracaine hydrochloride, nke nwere mmejọ nke akụrụngwa na-adịghị akwụsi ike ma ọ bụ obere mkpụrụ.Ndị ọkà mmụta sayensị emeziwanye nke a.Na 1981, ha tụrụ aro ka synthesize p-butylamino benzoic acid site na alkylating p-aminobenzoic acid na 1-Bromobutane.Otú ọ dị, n'ihi na-apụghị izere ezere e guzobere site-ngwaahịa nke dibutylation na-ejighị n'aka agwa nke akụrụngwa, a ụzọ adịghị adabara maka ulo oru mmepụta.
2. Tetracaine hydrochloride na-eji maka mucosal elu anesthesia, conduction anesthesia, epidural anesthesia na subarachnoid anesthesia;A na-eji ya maka nhụsianya elu anya, ọ naghị egbochi arịa ọbara, ọ dịghị emebi epithelium corneal, ọ dịghịkwa abawanye nrụgide intraocular.
3. Nke a ọgwụ nwere ike welie akwara mgbochi mmetụta nke cisatracurium, na usoro onunu ogwu nke ikpeazụ kwesịrị ibelata mgbe ejikọtara.Mgbe ejikọtara ya na adrenaline, ọ nwere ike igbochi arịa ọbara, belata nrịanrịa ọbara, mmịnye ọgwụ na-adịghị ngwa ngwa, na ogologo oge nke ime ihe.Ma nchikota nke abụọ adịghị adabara ndị ọrịa nwere ọrịa obi, ọbara mgbali elu, hyperthyroidism, peripheral vaskụla ọrịa na na.Hyaluronidase nwere ike ịbawanye mgbasa nke ọgwụ a n'ụzọ dị irè, mee ka mmalite nke anesthesia mee ngwa ngwa, belata ọzịza mpaghara, ma gbochie nguzobe nke hematoma.Agbanyeghị, hyaluronidase nwekwara ike ime ka nnabata nke ọgwụ a dị ngwa, na-ebute mmụba nke akwụkwọ nsị ọgwụ mgbochi ọgwụ.Ọgwụ a bụ ihe sitere na p-aminobenzoic acid (PABA).Sulfonamides na-arụ ọrụ antibacterial site na igbochi PABA nke nje bacteria.Mgbe ejikọtara ọgwụ a na sulfonamides, a ga-egbochi mmetụta antibacterial nke ikpeazụ, n'ihi ya, e kwesịghị ijikọta ha abụọ.Ọgwụ a bụ acidic na ekwesịghị ịgwakọta ya na ọgwụ mmiri mmiri alkaline;Ọbụna ọgwụ acidic nwere ike imetụta uru dissociation nke ọgwụ ahụ n'ihi pH dị iche iche, na-ebute mbelata ọrụ ma ọ bụ igbu oge mmalite.Nkwadebe nke Iodine nwere ike ime ka mmiri ozuzo nke ọgwụ a, ya mere a pụghị iji saịtị ịgba ọgwụ a.
Ngwa
Ngwaahịa a bụ ọgwụ anestetiiki mpaghara ester na-eme ogologo oge.Njirimara omume ya bụ: ntinye siri ike na mucosa, dabara adaba maka nhụsianya elu, na enweghị mmeghachi omume ọjọọ dị ka vasoconstriction, mydriasis, mmerụ ahụ corneal mgbe anya dara.A na-ejikarị ya eme ihe na ophthalmology.Mmetụta anestetiiki mpaghara na nsi dị ihe dị ka okpukpu iri karịa procaine.Mgbe ịgba ọgwụ mgbochi ahụ gasịrị, mmetụta anestetiiki nke akwụkwọ kemikal na-apụta nwayọọ nwayọọ (ihe dị ka nkeji iri), na metabolism na-adịkwa ngwa ngwa mgbe ọ gbasasịrị.Oge nkụnwụ mpaghara dị ruo 3ij, h, -j.gbasara.A na-ejikarị ya eme ihe maka mgbakasị elu nke anya, imi na akpịrị mucosa, ọ naghị adịkarịkwa eji ya eme ihe maka mgbakasị conduction na epidural anesthesia.N'ozuzu, a naghị eji ya eme ihe maka mgbakasị infiltration n'ihi oke nsi ya.
